Abstract | BACKGROUND: METHODS: Multicenter, international, open-label study. Four hundred and thirty seven patients were included. The plasma lipid levels at inclusion were fasting triglyceride concentrations between 1.6-3.9 mM/l and HDL cholesterol < or = 1.05 mM/l for women and < or = 0.9 mM/l for men. The LDL cholesterol was below 4.2 mM/l. All patients received ciprofibrate 100 mg/d. Efficacy and safety parameters were assessed at baseline and at the end of the treatment. The primary efficacy parameter of the study was percentage change in triglycerides from baseline. RESULTS: After 4 months, plasma triglyceride concentrations were decreased by 44% (p < 0.001). HDL cholesterol concentrations were increased by 10% (p < 0.001). Non- HDL cholesterol was decreased by 19%. A greater HDL cholesterol response was observed in lean patients (body mass index < 25 kg/m2) compared to the rest of the population (8.2 vs 19.7%, p < 0.001). In contrast, cases with excess body weight had a larger decrease in non- HDL cholesterol levels (-20.8 vs -10.8%, p < 0.001). There were no significant complications resulting from treatment with ciprofibrate. CONCLUSIONS:
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Authors | Carlos A Aguilar-Salinas, Andréia Assis-Luores-Vale, Benjamín Stockins, Hector Mario Rengifo, José Dondici Filho, Abrahão Afiune Neto, Lísia Marcílio Rabelo, Kerginaldo Paulo Torres, José Egídio Paulo de Oliveira, Carlos Alberto Machado, Eliana Reyes, Victor Saavedra, Fernando Florenzano, Ma Victoria Hernández, Sergio Hernandez Jiménez, Erika Ramírez, Cuauhtémoc Vazquez, Saul Salinas, Ismael Hernández, Octavio Medel, Ricardo Moreno, Paula Lugo, Ricardo Alvarado, Roopa Mehta, Victor Gutierrez, Francisco J Gómez Pérez |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 3
Pg. 8
(Jul 23 2004)
ISSN: 1475-2840 [Electronic] England |
PMID | 15272932
(Publication Type: Journal Article)
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