Abstract | PURPOSE: METHODS: Anesthetized adult male rats were subjected to either lateral FP brain injury of moderate severity (n = 37) or sham injury (n = 22, surgery without brain injury). Animals were randomized to receive i.p. injections of either BSF476921 (30 mg/kg bw; injured n = 15, sham n = 11) or sterile water (injured n = 14, sham n = 11) at 1, 11 and 22 hours post-injury. After assessment of motor function using a standard 28-point neuroscore, animals were sacrificed 24 hours following trauma and their brains evaluated for regional water content using the wet-weight/dry-weight technique. RESULTS: Although brain-injured animals showed a significant motor deficit compared to uninjured animals, no differences were detected between BSF476921- and vehicle-treated animals at the acute 24 hour post-injury time point. However, BSF476921 significantly attenuated regional edema formation in brain-injured animals in the ipsilateral hippocampus (p < 0.05) and in the cortex adjacent to the injury (p < 0.05) when compared to vehicle treatment. CONCLUSIONS:
|
Authors | Philipp M Lenzlinger, Kathryn E Saatman, Rachel C Hoover, Jessica A Cheney, Florence M Bareyre, Ramesh Raghupathi, Lee D Arnold, Tracy K McIntosh |
Journal | Restorative neurology and neuroscience
(Restor Neurol Neurosci)
Vol. 22
Issue 2
Pg. 73-9
( 2004)
ISSN: 0922-6028 [Print] Netherlands |
PMID | 15272142
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Copyright | Copyright 2004 IOS Press |
Chemical References |
- BSF 476921
- Organic Chemicals
- Vascular Endothelial Growth Factor Receptor-2
|
Topics |
- Animals
- Blood-Brain Barrier
(drug effects)
- Brain Edema
(drug therapy, mortality)
- Brain Injuries
(drug therapy, mortality)
- Disease Models, Animal
- Male
- Organic Chemicals
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Recovery of Function
(drug effects)
- Signal Transduction
(drug effects)
- Vascular Endothelial Growth Factor Receptor-2
(antagonists & inhibitors)
|