Abstract | BACKGROUND: METHODS: In this work, we studied four markers (two single nucleotide polymorphisms (SNPs): rs308963 and rs795009; and two insertion/deletion polymorphisms: rs2307981 and rs2308169) covering 144.2 kilobase pairs (kb) with an average interval of 38 kb in synapsin II in a sample of 654 schizophrenic patients and 628 normal control subjects to explore the mechanism underlying schizophrenia. RESULTS: We found significant differences in allele frequency distribution of SNP rs795009 (p =.000018, odds ratio 1.405, 95% confidence interval 1.202-1.641) between patients and control subjects. The T allele was significantly higher in patients than in control subjects. Moreover, the overall frequency of haplotype showed significant differences between patients and control subjects (p <.000001). CONCLUSIONS:
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Authors | Qi Chen, Guang He, Xiao Yan Wang, Qing Ying Chen, Xin Min Liu, Zhong Zhong Gu, Jie Liu, Ke Qing Li, Shi Ji Wang, Shao Ming Zhu, Guo Ying Feng, Lin He |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 56
Issue 3
Pg. 177-81
(Aug 01 2004)
ISSN: 0006-3223 [Print] United States |
PMID | 15271586
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Chi-Square Distribution
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Odds Ratio
- Polymorphism, Single Nucleotide
- Schizophrenia
(genetics, metabolism)
- Synapsins
(genetics, metabolism)
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