Abstract | BACKGROUND: OBJECTIVES: METHODS: This pilot double-blinded self-controlled study was initiated in 11 patients with moderate plaque psoriasis. To characterize the biological effects further and to evaluate the efficacy of topical paricalcitol treatment in psoriasis, we have analysed immunohistochemically the expression of one of the markers for epidermal differentiation ( transglutaminase K) in paricalcitol-treated skin as compared with placebo treatment. RESULTS: Treatment with paricalcitol was superior to placebo treatment beginning at week 1. The global severity score for erythema, plaque elevation and scaling was improved significantly more by paricalcitol ointment than by placebo (P < 0.001). Similar results were obtained for assessments of scaling, erythema and plaque elevation. No symptoms of local skin irritation were noted. Laboratory parameters including serum calcium, phosphorus, parathyroid hormone and urinary calcium/ creatinine ratio did not reveal any changes of clinical relevance during treatment. The immunoreactivity of transglutaminase K changed after 12 weeks of paricalcitol treatment almost completely to the pattern characteristic for nonlesional psoriatic skin. CONCLUSIONS:
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Authors | C Durakovic, S Ray, M F Holick |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 151
Issue 1
Pg. 190-5
(Jul 2004)
ISSN: 0007-0963 [Print] England |
PMID | 15270890
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biomarkers
- Ergocalciferols
- Immunosuppressive Agents
- paricalcitol
- Transglutaminases
- transglutaminase 1
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Topics |
- Administration, Topical
- Adult
- Aged
- Biomarkers
(analysis)
- Cell Division
- Double-Blind Method
- Ergocalciferols
(administration & dosage, therapeutic use)
- Humans
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Middle Aged
- Pilot Projects
- Psoriasis
(drug therapy, enzymology, pathology)
- Skin
(enzymology, pathology)
- Transglutaminases
(analysis)
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