Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review.

Abstract

Two patients with xanthogranulomatous inflammation are described, one with involvement of the spermatic cord and the other with 1 testicle and epididymis affected. To our knowledge, only 12 cases of xanthogranulomatous orchiepididymitis have been reported previously, one of which also presented a xanthogranulomatous funiculitis. Clinically, our patients presented with spermatic cord enlargement (case 1) and chronic orchitis that did not respond to treatment with antibiotics (case 2). Histopathologically, both cases showed extensive xanthogranulomatous inflammation with numerous foamy macrophages that were associated with colonies of microorganisms suggestive of actinomyces in case 1. Additionally, Escherichia coli was cultured from the surgical specimen of case 2. The possible underlying pathology may be diabetes in case 1 and phlebitis associated with chronic orchitis in case 2. Differential diagnoses with other lesions that are rich in macrophages, such as malakoplakia, and those testicular neoplasms without serologic tumor markers are discussed.

• Authors: Manuel Nistal, Pilar Gonzalez-Peramato, Alvaro Serrano, Javier Regadera
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 128 Issue 8 Pg. 911-4 (Aug 2004) ISSN: 1543-2165 [Electronic] United States
• PMID: 15270607 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Abscess (etiology, microbiology, pathology, surgery)
• Actinomycosis (complications, pathology, surgery)
• Aged
• Diabetes Complications (pathology)
• Epididymitis (complications, microbiology, pathology, surgery)
• Escherichia coli Infections (complications, pathology, surgery)
• Foam Cells (pathology)
• Genital Diseases, Male (complications, microbiology, pathology, surgery)
• Granuloma (complications, microbiology, pathology, surgery)
• Humans
• Male
• Middle Aged
• Orchitis (complications, microbiology, pathology, surgery)
• Phlebitis (complications)
• Spermatic Cord (microbiology, pathology, surgery)
• Xanthomatosis (complications, microbiology, pathology, surgery)