Magnetic resonance imaging detects early changes in microvascular permeability in xenograft tumors after treatment with the matrix metalloprotease inhibitor Prinomastat.

Abstract

Macromolecular contrast medium-enhanced magnetic resonance imaging was applied to monitor the effect of matrix metalloprotease (MMP) inhibition on microvascular characteristics of human breast cancers implanted in athymic rats. Twice-daily intraperitoneal administration of Prinomastat over 1.5 days induced significant declines in MRI-assayed microvascular permeabilities (p<0.05); but this leak suppression effect had extinguished by the 10(th) day of MMP treatment using the same dose and time schedule. Results demonstrate that Prinomastat produces a rapid but transient decrease in tumor vascular permeability. Contrast-enhanced MRI using macromolecular contrast medium may prove useful as a biomarker for the dynamic MMP biological effect in cancers.

• Authors: Marlene Wiart, Laure S Fournier, Viktor Y Novikov, David M Shames, Timothy P Roberts, Yanjun Fu, David R Shalinsky, Robert C Brasch
• Journal: Technology in cancer research & treatment (Technol Cancer Res Treat) Vol. 3 Issue 4 Pg. 377-82 (Aug 2004) ISSN: 1533-0346 [Print] United States
• PMID: 15270589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Contrast Media
• Enzyme Inhibitors
• Matrix Metalloproteinase Inhibitors
• Organic Chemicals
• prinomastat

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Breast Neoplasms (drug therapy)
• Capillary Permeability
• Cell Division
• Cell Line, Tumor
• Contrast Media (pharmacology)
• Enzyme Inhibitors (pharmacology)
• Female
• Homozygote
• Humans
• Magnetic Resonance Imaging (instrumentation, methods)
• Matrix Metalloproteinase Inhibitors
• Microcirculation
• Neoplasm Transplantation
• Neoplasms (therapy)
• Organic Chemicals (therapeutic use)
• Rats
• Rats, Nude
• Statistics as Topic
• Time Factors