Chemical constituents of Millettia taiwaniana: structure elucidation of five new isoflavonoids and their cancer chemopreventive activity.

Abstract

We describe the isolation and identification of five new isoflavonoids, millewanins A (1), B (2), C (3), D (4), and E (5), together with six known isoflavonoids and three rotenoids, from the stems of Millettia taiwaniana collected in Japan. The major component, auriculasin (6), exhibited significant inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that 6 might be a valuable antitumor promoter.

• Authors: Chihiro Ito, Masataka Itoigawa, Naoki Kojima, Harukuni Tokuda, Tetsurou Hirata, Hoyoku Nishino, Hiroshi Furukawa
• Journal: Journal of natural products (J Nat Prod) Vol. 67 Issue 7 Pg. 1125-30 (Jul 2004) ISSN: 0163-3864 [Print] United States
• PMID: 15270565 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticarcinogenic Agents
• Isoflavones

Topics

• Animals
• Anticarcinogenic Agents (chemistry, isolation & purification, pharmacology)
• Isoflavones (chemistry, isolation & purification, pharmacology)
• Japan
• Mice
• Millettia (chemistry)
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Plant Stems (chemistry)
• Plants, Medicinal (chemistry)
• Skin (drug effects)