Choanal atresia associated with prenatal methimazole exposure: three new patients.

Abstract

We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus.

• Authors: P Barbero, C Ricagni, G Mercado, R Bronberg, M Torrado
• Journal: American journal of medical genetics. Part A (Am J Med Genet A) Vol. 129A Issue 1 Pg. 83-6 (Aug 15 2004) ISSN: 1552-4825 [Print] United States
• PMID: 15266622 (Publication Type: Journal Article, Review)

Chemical References

• Antithyroid Agents
• Methimazole

Topics

• Antithyroid Agents (adverse effects, therapeutic use)
• Choanal Atresia (chemically induced)
• Female
• Humans
• Infant
• Infant, Newborn
• Methimazole (adverse effects, therapeutic use)
• Pregnancy
• Pregnancy Complications (drug therapy)
• Prenatal Exposure Delayed Effects
• Thyrotoxicosis (drug therapy)