Abstract | OBJECTIVE: CASE SUMMARY: An 83-year-old woman presented with a severe bleeding disorder 2 weeks after she was prescribed acetaminophen and chlorpheniramine for treatment of a flu-like illness. Laboratory studies showed severe anemia with greatly reduced factor VIII activity and the presence of a high-titer factor VIII inhibitor at 228 Bethesda units. Treatment with high-dose corticosteroids, transfusion of several units of red blood cells, and repeated infusions of factor VIII bypassing activity was successful. Complete clinical and laboratory remission was achieved after 4 weeks of treatment. Use of the Naranjo probability scale suggested a possible association between this adverse event and treatment with acetaminophen and chlorpheniramine. DISCUSSION: CONCLUSIONS:
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Authors | Giuseppe Famularo, Silvia De Maria, Giovanni Minisola, Giulio Cesare Nicotra |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 38
Issue 9
Pg. 1432-4
(Sep 2004)
ISSN: 1060-0280 [Print] United States |
PMID | 15266042
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Analgesics, Non-Narcotic
- Blood Coagulation Factors
- Histamine H1 Antagonists
- Steroids
- Acetaminophen
- prothrombin complex concentrates
- Chlorpheniramine
- Factor VIII
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Topics |
- Acetaminophen
(adverse effects)
- Aged
- Aged, 80 and over
- Analgesics, Non-Narcotic
(adverse effects)
- Blood Coagulation Factors
(therapeutic use)
- Chlorpheniramine
(adverse effects)
- Factor VIII
(antagonists & inhibitors)
- Female
- Hemophilia A
(drug therapy, etiology)
- Histamine H1 Antagonists
(adverse effects)
- Humans
- Steroids
(therapeutic use)
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