| Abstract | Both the type I (IFN-alpha beta) and type II (IFN-gamma) IFNs have been heavily implicated in the pathogenesis of systemic lupus erythematosus. To test the relative roles of these systems, congenic lupus-prone MRL/CD95(lpr/lpr) (MRL/lpr) mice lacking the type I IFN receptor (IFN-RI), type II IFN receptor (IFN-RII), or both, were derived. As expected, deficiency for IFN-RII protected MRL/lpr mice from the development of significant autoimmune-associated lymphadenopathy, autoantibodies, and renal disease. However, deficiency for the IFN-RI surprisingly worsened lymphoproliferation, autoantibody production, and end organ disease; animals doubly deficient for IFN-RI and IFN-RII developed an autoimmune phenotype intermediate between wild-type and IFN-RII-deficient animals, all correlating with an ability of type I IFN to suppress MRL B cell activation. Thus, type I IFNs protect against both the humoral and end organ autoimmune syndrome of MRL/lpr mice, independent of IFN-gamma. These findings warrant caution in the use of type I IFN antagonists in the treatment of autoimmune diseases and suggest further investigation into the interplay between the types I and II IFNs during the ontogeny of pathogenic autoantibodies. |
| Authors | Jonathan D Hron, Stanford L Peng
(Affiliation: Department of Internal Medicine , Washington University School of Medicine, St. Louis, MO 63110, USA.)
|
| Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 173
Issue 3
Pg. 2134-42
(Aug 1 2004)
ISSN: 0022-1767 United States |
| PMID | 15265950
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Antibodies, Antinuclear
- Interferon-alpha
- Membrane Proteins
- Receptors, Interferon
- interferon receptor, type II
- Receptor, Interferon alpha-beta
- Interferon-beta
- Rheumatoid Factor
|
| Topics |
- Animals
- Antibodies, Antinuclear
(biosynthesis)
- Autoimmune Diseases
(genetics, pathology, physiopathology, prevention & control)
- B-Lymphocytes
(immunology)
- Crosses, Genetic
- Disease Models, Animal
- Female
- Interferon-alpha
(physiology)
- Interferon-beta
(physiology)
- Kidney Glomerulus
(pathology)
- Liver
(pathology)
- Lung
(pathology)
- Lupus Erythematosus, Systemic
(genetics, pathology, physiopathology, prevention & control)
- Lupus Nephritis
(pathology, physiopathology, prevention & control)
- Lymphocyte Activation
- Lymphoproliferative Disorders
(genetics, physiopathology)
- Male
- Membrane Proteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred MRL lpr
- Receptor, Interferon alpha-beta
- Receptors, Interferon
(deficiency, genetics, physiology)
- Rheumatoid Factor
(biosynthesis)
- Salivary Glands
(pathology)
|
