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Erdosteine improves oxidative damage in a rat model of renal ischemia-reperfusion injury.

Abstract
The aim of the present study was to determine the effects of erdosteine, a new antioxidant and anti-inflammatory agent, on lipid peroxidation, neutrophil infiltration, and antioxidant enzyme activities in a rat model of renal ischemia-reperfusion (I/R) injury. Twenty-eight rats were divided into three groups: sham operation, I/R, and I/R plus erdosteine groups. After the experimental procedure, rats were sacrificed and kidneys were removed and prepared for malondialdehyde (MDA) levels, myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) activities. MDA level, MPO and XO activities were significantly increased in the I/R group. On the other hand, SOD and CAT activities were found to be decreased in the I/R group compared to the sham group. Pretreatment with erdosteine significantly diminished tissue MDA level, MPO and XO activities. Our data support a role for erdosteine in attenuation in renal damage after I/R injury of the kidney, in part at least by inhibition of neutrophil sequestration and XO activity.
AuthorsA Gurel, F Armutcu, A Cihan, K V Numanoglu, M Unalacak
JournalEuropean surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes (Eur Surg Res) 2004 Jul-Aug Vol. 36 Issue 4 Pg. 206-9 ISSN: 0014-312X [Print] Switzerland
PMID15263825 (Publication Type: Journal Article)
CopyrightCopyright 2004 S. Karger AG, Basel
Chemical References
  • Expectorants
  • Thioglycolates
  • Thiophenes
  • erdosteine
  • Catalase
  • Peroxidase
  • Superoxide Dismutase
  • Xanthine Oxidase
Topics
  • Animals
  • Catalase (metabolism)
  • Disease Models, Animal
  • Expectorants (pharmacology)
  • Kidney (drug effects, metabolism)
  • Lipid Peroxidation (drug effects)
  • Male
  • Oxidative Stress (drug effects)
  • Peroxidase (metabolism)
  • Rats
  • Rats, Wistar
  • Reperfusion Injury (drug therapy, metabolism)
  • Superoxide Dismutase (metabolism)
  • Thioglycolates (pharmacology)
  • Thiophenes (pharmacology)
  • Xanthine Oxidase (metabolism)

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