HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Transcranial magnetic stimulation for auditory hallucinations in schizophrenia.

Abstract
It has been suggested that low frequency transcranial magnetic stimulation (TMS) over left temporo-parietal cortex may reduce the frequency and intensity of auditory hallucinations in schizophrenia. Sixteen patients with hallucinations, treatment-resistant for at least 2 months, were randomised into a placebo-controlled crossover study of TMS at 1 Hz and 80% of motor threshold over left temporo-parietal cortex. Treatment periods lasted for 4 days, with daily duration escalating from 4 to 8, 12 and 16 min on subsequent days. Each minute of stimulation was followed by 15 s of rest to check coil position and allow the patient to move, if necessary. Both patients and symptom raters were unaware of the treatment condition. Patients' hallucination scores improved from baseline with both real and sham TMS, and there was no significant difference between real and sham treatments. There was a trend for second treatments, whether sham or real, to be more effective than first treatments. Other psychopathology scales (apart from positive symptoms) and verbal memory were not affected by real or sham TMS. Previous positive studies could not be replicated with these parameters. TMS is safe if applied within the protocol used.
AuthorsAndrew M McIntosh, David Semple, Katherine Tasker, Lesley K Harrison, David G C Owens, Eve C Johnstone, Klaus P Ebmeier
JournalPsychiatry research (Psychiatry Res) Vol. 127 Issue 1-2 Pg. 9-17 (Jun 30 2004) ISSN: 0165-1781 [Print] Ireland
PMID15261700 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2004 Elsevier Ireland Ltd.
Topics
  • Adolescent
  • Adult
  • Aged
  • Cross-Over Studies
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Hallucinations (etiology, therapy)
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia (complications, diagnosis)
  • Skull
  • Transcranial Magnetic Stimulation (instrumentation)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: