Factors affecting haemorrhagic transformation in middle cerebral artery infarctions.

Haemorrhagic transformation (HT) affects treatment and prognosis in patients with acute ischaemic stroke. The factors affecting haemorrhagic transformation in infarcts due to occlusion of middle cerebral artery (MCA) stem or branch were investigated.
Of 412 patients who were followed in our clinic between January 2001 and December 2001 with acute ischaemic stroke, 86 patients with occlusion in MCA stem or branch were enrolled in this study. These patients were divided into 2 groups, those with HT (n = 35) and without HT (n = 51). Age, sex, systemic arterial hypertension, diabetes mellitus, blood glucose level in the acute period, renal and liver function tests, systolic and diastolic arterial blood pressure in the acute period, previous cerebrovascular disease, leukoaraiosis, modified Rankin Disability Score (mRDS) and stroke subtype were evaluated.
High blood glucose level in the acute period and presence of leukoaraiosis on cranial computerized (CCT) tomography were detected as risk factors in development of HT. HT was seen more frequently in MCA stem infarction than branch infarction. mRDS were worse in the group with HT. In multivariate analysis, there were independent relationships between mean blood glucose level on admission, mRDS, presence of diabetes mellitus, and MCA stem infarction and development of haemorrhagic transformation in patients with MCA territorial infarction.
AuthorsYahya Celik, Ufuk Utku, Talip Asil, Kemal Balci
JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 11 Issue 6 Pg. 656-8 (Aug 2004) ISSN: 0967-5868 [Print] Scotland
PMID15261244 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Aged
  • Blood Glucose
  • Brain Ischemia (complications)
  • Cerebral Hemorrhage (classification, etiology)
  • Diabetes Mellitus
  • Disability Evaluation
  • Female
  • Humans
  • Hypertension
  • Infarction, Middle Cerebral Artery (complications)
  • Leukoaraiosis
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Retrospective Studies
  • Risk Factors
  • Tomography, X-Ray Computed

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