Comparison of two single-day regimens of triclabendazole for the treatment of human pulmonary paragonimiasis.

A well-tolerated single-day treatment regimen is required for the community-based treatment of pulmonary paragonimiasis. To identify an optimal single-day treatment regimen, an open clinical trial was performed to compare the efficacy of 2 single-day regimens of triclabendazole. From 1991 to 1993, a total of 154 Ecuadorian patients were allocated to receive either a single dose or 2 doses of 10 mg/kg triclabendazole. Treatment with both regimens was associated with a rapid parasitological response (determined by clearance of Paragonimus eggs from sputum), resolution of most clinical symptoms and radiological signs, and only mild adverse effects. At 3 months after treatment, the cure rate (clearance of eggs from sputum) was 90.9% in the 2-dose group and 84.4% in the single-dose group. Re-treatment with a second 2-dose regimen was curative in all remaining patients by 1 year of follow-up. Our findings show that both single-day treatment regimens of triclabendazole were highly effective in the treatment of pulmonary paragonimiasis and suggest that patients should be re-examined at 3 months to determine the need for repeat treatment.
AuthorsManuel Calvopiña, Ronald H Guderian, Wilson Paredes, Philip J Cooper
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) 2003 Jul-Aug Vol. 97 Issue 4 Pg. 451-4 ISSN: 0035-9203 [Print] England
PMID15259481 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anthelmintics
  • Benzimidazoles
  • triclabendazole
  • Adolescent
  • Adult
  • Aged
  • Anthelmintics (administration & dosage, adverse effects, therapeutic use)
  • Benzimidazoles (administration & dosage, adverse effects, therapeutic use)
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Diseases, Parasitic (drug therapy, parasitology)
  • Male
  • Middle Aged
  • Paragonimiasis (drug therapy, parasitology)
  • Parasite Egg Count
  • Sputum (parasitology)
  • Treatment Outcome

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