Abstract | OBJECTIVE: To explore the effects of interaction between environmental exposure factors and genetic polymorphism in toxicant metabolizing enzymes on risk of occupational chronic benzene poisoning. METHODS: One hundred and fifty-two cases of chronic benzene poisoning were analyzed for the risk by case-only study. RESULTS: The frequency of non-null GSTT1 gene in benzene poisoning workers with moderate benzene exposure level was higher than that in cases with lower benzene exposure (68.63% vs 38.00%, OR(adj) = 4.32, 95% CI 1.75 - 10.66, P = 0.002). The frequency of NQO1 C.609T/T gene in alcohol drinking group was higher than that in non-drinking group (61.11% vs 20.00%, OR(adj) = 8.03, 95% CI 2.28 - 28.25, P = 0.001), moreover, it was higher in workers with smoking and drinking than that in the rest group, and in drinking x exposure level workers than that in non-drinking x exposure level workers (85.71% vs 22.76%, OR(adj) = 18.62, 95% CI 2.01 - 172.72, P = 0.01 and 61.11% vs 20.00%, OR(adj) = 3.18, 95% CI 1.55 - 6.52, P = 0.002 respectively). The frequency of non-null GSTM1 gene was also higher in drinking x exposure level workers than that in non-drinking x exposure level workers (66.67% vs 47.06%, OR(adj) = 1.99, 95% CI 1.05 - 3.76, P = 0.036). CONCLUSION: There is interaction between the polymorphism of GSTT1 gene and moderate benzene exposure level; non-null GSTM1 gene and drinking x exposure level increase the risk of occupational chronic benzene poisoning; polymorphism of NQO1 gene C.609 also interacts with drinking, while polymorphism of NQO1 gene and drinking x smoking may further increase the risk of occupational chronic benzene poisoning.
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Authors | Zhong-bin Zhang, Jun-xiang Wan, Zhao-lin Xia |
Journal | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
(Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)
Vol. 22
Issue 3
Pg. 168-72
(Jun 2004)
ISSN: 1001-9391 [Print] China |
PMID | 15256146
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytochrome P-450 CYP2E1
- NAD(P)H Dehydrogenase (Quinone)
- NQO1 protein, human
- Glutathione Transferase
- glutathione S-transferase M1
- Benzene
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Topics |
- Adult
- Benzene
(metabolism, poisoning)
- Cytochrome P-450 CYP2E1
(biosynthesis, genetics, pharmacology)
- Female
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
(biosynthesis, genetics, pharmacology)
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
(biosynthesis, genetics, pharmacology)
- Occupational Diseases
(enzymology, genetics)
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Risk Factors
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