Abstract | OBJECTIVES: METHODS: After a 2-week washout, 24 patients received 3 weeks of double-blind treatment with modafinil 400-mg once daily (7 AM) plus placebo (noon) or modafinil 600-mg split dose (400 mg, 7 AM; 200 mg, noon). Assessments included a Maintenance of Wakefulness Test (MWT) for individual regimens and the Wisconsin Card Sort Test (WCST) for treatments combined. RESULTS:
Modafinil 600-mg split dose was significantly more effective than modafinil 400-mg once daily in improving late-day MWT scores (5 PM-7 PM; P < 0.05). Significant mean (+/- SEM) reductions from baseline of 8.2 +/- 2.7 in the total number of errors and 5.9 +/- 1.9 in total percent of errors (P < 0.05, both) were demonstrated for modafinil on the WCST. Modafinil was well tolerated; adverse events included headache (n = 1), emotional lability (n = 1), bronchitis (n = 1), and accidental injury (n = 2), with no reports of insomnia. CONCLUSIONS: For patients with residual late-day sleepiness associated with narcolepsy, an additional 200-mg dose of modafinil taken at midday was effective in sustaining wakefulness throughout the entire waking day. Treatment with modafinil also significantly improved executive function.
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Authors | Jonathan R L Schwartz, Michael T Nelson, Elliott R Schwartz, Rod J Hughes |
Journal | Clinical neuropharmacology
(Clin Neuropharmacol)
2004 Mar-Apr
Vol. 27
Issue 2
Pg. 74-9
ISSN: 0362-5664 [Print] United States |
PMID | 15252267
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Benzhydryl Compounds
- Central Nervous System Stimulants
- Modafinil
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Topics |
- Adolescent
- Adult
- Aged
- Benzhydryl Compounds
(administration & dosage, therapeutic use)
- Central Nervous System Stimulants
(administration & dosage, therapeutic use)
- Circadian Rhythm
- Cognition
(drug effects)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Male
- Middle Aged
- Modafinil
- Narcolepsy
(drug therapy, physiopathology)
- Sleep
(drug effects)
- Treatment Outcome
- Wakefulness
(drug effects, physiology)
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