Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The cumulative prevalence of dementia in Parkinson's disease can be as high as 78%; dementia is especially prevalent in older patients. The profile of dementia seems to be different from that of Alzheimer's disease and similar to that of dementia with Lewy bodies. Clinicopathological correlation studies have suggested that dementia correlates best with Lewy bodies in certain limbic and cortical areas, but not all patients with sufficient Lewy bodies for a pathological diagnosis of dementia with Lewy bodies are demented. Cholinergic deficits in the cerebral cortex can be shown with in-vivo imaging studies, and seem to be more severe than in Alzheimer's disease. Several small studies with three different cholinesterase inhibitors suggest that these drugs can be effective in the treatment of PD dementia. SUMMARY:
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Authors | Murat Emre |
Journal | Current opinion in neurology
(Curr Opin Neurol)
Vol. 17
Issue 4
Pg. 399-404
(Aug 2004)
ISSN: 1350-7540 [Print] England |
PMID | 15247534
(Publication Type: Journal Article, Review)
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Chemical References |
- Cholinesterase Inhibitors
- Acetylcholine
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Topics |
- Acetylcholine
(deficiency)
- Animals
- Cerebral Cortex
(metabolism, pathology, physiopathology)
- Cholinesterase Inhibitors
(therapeutic use)
- Dementia
(drug therapy, pathology, physiopathology)
- Humans
- Lewy Bodies
(pathology)
- Limbic System
(metabolism, pathology, physiopathology)
- Parkinson Disease
(complications)
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