Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa.

Abstract

Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.

• Authors: Valdo Ricca, Benedetta Nacmias, Maura Boldrini, Elena Cellini, Milena di Bernardo, Claudia Ravaldi, Andrea Tedde, Silvia Bagnoli, Gian Franco Placidi, Carlo Maria Rotella, Sandro Sorbi
• Journal: Neuroscience letters (Neurosci Lett) Vol. 365 Issue 2 Pg. 92-6 (Jul 22 2004) ISSN: 0304-3940 [Print] Ireland
• PMID: 15245785 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptor, Serotonin, 5-HT2A

Topics

• Adult
• Anorexia Nervosa (diagnosis, genetics, psychology)
• Bulimia (diagnosis, genetics, psychology)
• Case-Control Studies
• Female
• Humans
• Polymorphism, Genetic
• Promoter Regions, Genetic
• Receptor, Serotonin, 5-HT2A (genetics)