Abstract | OBJECTIVE: Plasma levels of folate and vitamin B12 are inversely related to homocysteinemia and nowadays a further supplement of these vitamins, other than diet, is considered useful for lowering homocysteine blood levels. Stressen possesses the requirements for the control of this biochemical parameter; this study had the purpose to verify the activity of the product in patients affected by vascular disease. MATERIALS AND METHODS: 40 patients have taken a bottle of Stressen twice daily for 30 days and 20 subjects, suffering from the same pathology and non treated with the drug, have been considered as controls. Homocysteinemia was evaluated at the beginning and at the end of the treatment. RESULTS: Stressen determined a statistical reduction of 51.1% of basal concentration (p<0.0001), while levels of controls remained unchanged after the 30 days period. CONCLUSIONS:
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Authors | F Monteleone |
Journal | La Clinica terapeutica
(Clin Ter)
2004 Feb-Mar
Vol. 155
Issue 2-3
Pg. 65-7
ISSN: 0009-9074 [Print] Italy |
Vernacular Title | Studio controllato dell'effetto della specialità medicinale "Stressen" sui livelli ematici di omocisteina in pazienti con patologia vascolare. |
PMID | 15244109
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Cobamides
- Dipeptides
- Drug Combinations
- Homocysteine
- Nitric Oxide Synthase
- cobamamide
- Leucovorin
- arginine glutamate
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Cobamides
(administration & dosage, therapeutic use)
- Dipeptides
(administration & dosage, therapeutic use)
- Drug Administration Schedule
- Drug Combinations
- Endothelium, Vascular
(drug effects)
- Female
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(blood, complications, drug therapy)
- Immunoenzyme Techniques
- Leucovorin
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Nitric Oxide Synthase
(metabolism)
- Treatment Outcome
- Vascular Diseases
(blood, complications)
- Vasodilation
(drug effects)
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