Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The results from several recent prospective epidemiological studies demonstrate apoB to be superior to any of the cholesterol indices to estimate the risk of vascular disease. Similarly, the results of several of the major statin clinical trials demonstrate that apoB is a more adequate index of the adequacy of statin therapy than any of the cholesterol indices. Recent studies of lipoprotein subclass distribution in subjects with familial combined hyperlipidemia are reviewed. They demonstrate the limitations of the original lipid-based criteria and point to the necessity of using apoB as a fundamental diagnostic criterion for the disorder. A diagnostic algorithm for an apoB100 atherogenic dyslipoproteinemias is presented and the limitations of the lipid-based system described. SUMMARY: The evidence supporting the clinical use of apoB is solid, its measurement is standardized, and automated, inexpensive laboratory testing could easily be widely available. However, clinical benefit will only follow clinical application.
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Authors | Allan D Sniderman |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 15
Issue 4
Pg. 433-8
(Aug 2004)
ISSN: 0957-9672 [Print] England |
PMID | 15243216
(Publication Type: Journal Article, Review)
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Chemical References |
- Apolipoprotein B-100
- Apolipoproteins B
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Triglycerides
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Topics |
- Algorithms
- Apolipoprotein B-100
- Apolipoproteins B
(genetics)
- Arteriosclerosis
(diagnosis, drug therapy, epidemiology, genetics)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Lipid Metabolism
- Triglycerides
(metabolism)
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