Abstract |
Twenty individual antiretroviral drugs and two coformulation products are approved by the US Food and Drug Administration for the treatment of HIV-infected individuals. Many of these drugs have been associated with allergic/ hypersensitivity reactions to varying degrees. The antiretroviral drugs that are most commonly associated with these types of reactions are abacavir, all of the nonnucleoside reverse transcriptase inhibitors, and amprenavir. Trimethoprim-sulfamethoxazole, although not an antiretroviral drug, is extensively used for the treatment and prophylaxis of HIV-related opportunistic infections and has been associated with a significant rate of adverse reactions. The authors provide an overview of these drug-related reactions and discuss their pathogenesis and management.
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Authors | Zelalem Temesgen, Gagan Beri |
Journal | Immunology and allergy clinics of North America
(Immunol Allergy Clin North Am)
Vol. 24
Issue 3
Pg. 521-31, viii
(Aug 2004)
ISSN: 0889-8561 [Print] United States |
PMID | 15242725
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Antiviral Agents
(adverse effects, immunology, therapeutic use)
- Drug Hypersensitivity
(immunology, physiopathology)
- HIV Infections
(complications, drug therapy)
- Humans
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