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The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease.

Abstract
Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. If Tg is confirmed as a susceptibility gene for AITD, it could provide a novel therapeutic target.
AuthorsYaron Tomer, David Greenberg
JournalTrends in molecular medicine (Trends Mol Med) Vol. 10 Issue 7 Pg. 306-8 (Jul 2004) ISSN: 1471-4914 [Print] England
PMID15242677 (Publication Type: Journal Article, Review)
Chemical References
  • Thyroglobulin
Topics
  • Animals
  • Autoimmune Diseases (genetics)
  • Genetic Predisposition to Disease
  • Humans
  • Mice
  • Mutation, Missense (genetics)
  • Thyroglobulin (genetics)
  • Thyroid Diseases (genetics)

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