Epothilone D (Kosan/Roche).

Abstract

Kosan and Roche are developing the microtubule inhibitor epothilone D (KOS-862 and NSC-703147), an analog of epothilone B for the potential treatment of cancer. Phase II trials in colorectal, metastatic breast and non-small-cell lung cancers were initiated in December 2003.

• Authors: Ada Kolman
• Journal: Current opinion in investigational drugs (London, England : 2000) (Curr Opin Investig Drugs) Vol. 5 Issue 6 Pg. 657-67 (Jun 2004) ISSN: 1472-4472 [Print] England
• PMID: 15242255 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Drugs, Investigational
• Epothilones
• desoxyepothilone B

Topics

• Animals
• Antineoplastic Agents (adverse effects, chemistry, pharmacology, therapeutic use)
• Clinical Trials, Phase I as Topic
• Clinical Trials, Phase II as Topic
• Clinical Trials, Phase III as Topic
• Drug Evaluation, Preclinical
• Drugs, Investigational (adverse effects, chemistry, pharmacology, therapeutic use)
• Epothilones (adverse effects, chemistry, pharmacology, therapeutic use)
• Humans