Sustained remissions with long-term weekly chlorambucil maintenance therapy in patients with mucosa-associated lymphoid tissue lymphoma.

Abstract

Five patients with mucosa-associated lymphoid tissue (MALT) lymphoma (Helicobacter pylori negative) were initially treated with daily chlorambucil (Chl, 0.06-0.08 mg/kg per day) and achieved complete remission (n = 4) or partial remission (n = 1). They were then given long-term weekly Chl as maintenance therapy with good results. One patient came off treatment and has remained in continued remission for 44 months. This simple, low-cost, and convenient approach deserves further evaluation in patients with MALT lymphoma and other indolent and incurable lymphoproliferative disorders.

• Authors: Arumugam Manoharan
• Journal: International journal of hematology (Int J Hematol) Vol. 79 Issue 5 Pg. 472-3 (Jun 2004) ISSN: 0925-5710 [Print] Japan
• PMID: 15239398 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Chlorambucil

Topics

• Adult
• Aged
• Antineoplastic Agents, Alkylating (administration & dosage, therapeutic use)
• Chlorambucil (administration & dosage, therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Lymphoma, B-Cell, Marginal Zone (drug therapy)
• Male
• Middle Aged
• Treatment Outcome