The effect of fusafungine on post-operative pain and wound healing after pediatric tonsillectomy.

Abstract

OBJECTIVE:

To investigate the effect of fusafungine spray on pain and healing process after pediatric tonsillectomy.

METHODS:

Sixty children with ages between 4 and 14 years underwent tonsillectomy or adenotonsillectomy. The patients were randomly divided into three groups and each group consisted of 20 patients. Group 1 was treated with antibiotic (amoxicillin-clavulanic acid) plus analgesic (acetaminophen), group 2 was treated with fusafungine plus analgesic (acetaminophen) and group 3 was treated with only fusafungine. The average ages were 7.8 + 3.4, 6.6 + 2.9, and 8.2 + 3.7 for groups 1, 2, and 3, respectively. Clinical evaluations were made after the operation on the 1st (T1), 3rd (T3), 7th (T7), 10th (T10), and 14th days (T14).

RESULTS:

There was no significant difference in post-operative pain between study groups on the post-operative 1st, 3rd, and 7th days (P > 0.05), a statistically significant difference was present between groups 1 and 3, and groups 1 and 2 on the post-operative 10th and 14th day (P = 0.018 and 0.037, respectively). Pain was less in groups 2 and 3 than in group 1 on the 10th and 14th day. Also there was a significant difference in healing time of the tonsillary beds between groups 1 and 2, and groups 1 and 3 on the 10th and 14th post-operative day (P = 0.031 and 0.001, respectively). Healing was better in groups 2 and 3 than in group 1 on the 10th and 14th day.

CONCLUSION:

Fusafungine administration after tonsillectomy was found to be beneficial on post-operative pain and wound healing of tonsillary beds in pediatric population.

• Authors: Yucel Akbas, Yavuz Selim Pata, Murat Unal, Kemal Gorur, Deniz Micozkadioglu
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 68 Issue 8 Pg. 1023-6 (Aug 2004) ISSN: 0165-5876 [Print] Ireland
• PMID: 15236888 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Aerosols
• Analgesics, Non-Narcotic
• Anti-Bacterial Agents
• Depsipeptides
• Acetaminophen
• fusafungin
• Amoxicillin-Potassium Clavulanate Combination

Topics

• Acetaminophen (therapeutic use)
• Adolescent
• Aerosols (pharmacology, therapeutic use)
• Amoxicillin-Potassium Clavulanate Combination (therapeutic use)
• Analgesics, Non-Narcotic (therapeutic use)
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Case-Control Studies
• Child
• Child, Preschool
• Depsipeptides
• Drug Therapy, Combination
• Female
• Fusarium
• Humans
• Male
• Pain, Postoperative (drug therapy, etiology)
• Tonsillectomy (adverse effects)
• Treatment Outcome
• Wound Healing (drug effects)