Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: Eleven of 11 patients with residual postoperative disease assessable for response achieved a CR. With a median follow-up of 6.5 years, eight out of 19 (0.42) patients remain in CR 1 without radiotherapy and another three patients are in stable second or subsequent remissions. Three patients died from treatment-related toxicity and another died in CR 1 from an uncharacterized leukoencephalopathy. The 5-year event-free survival (EFS) was 0.47 +/- 0.23 and 5-year overall survival (OS) was 0.68 +/- 0.22. CONCLUSIONS: Intensive cisplatin and cyclophosphamide-based chemotherapy was effective in achieving remissions, however, the long-term outcome using this treatment program was unsatisfactory and associated with unacceptable morbidity and mortality, particularly in patients with diabetes insipidus.
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Authors | Stewart J Kellie, Hayden Boyce, Ira J Dunkel, Blanca Diez, Marc Rosenblum, Lynette Brualdi, Jonathan L Finlay |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 43
Issue 2
Pg. 126-33
(Aug 2004)
ISSN: 1545-5009 [Print] United States |
PMID | 15236278
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright 2004 Wiley-Liss, Inc. |
Chemical References |
- Cyclophosphamide
- Cisplatin
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Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Australia
(epidemiology)
- Brain Neoplasms
(drug therapy, mortality, pathology)
- Child
- Child, Preschool
- Cisplatin
(administration & dosage)
- Cyclophosphamide
(administration & dosage)
- Disease-Free Survival
- Female
- Germinoma
(drug therapy, mortality, pathology)
- Humans
- Infant
- Male
- Survival Rate
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