Abstract | PURPOSE: Muscle insulin resistance is characterized by the inability of a normal insulin concentration to produce a favorable rate of glucose uptake. The muscle of the obese Zucker rat is highly insulin resistant. The purpose of this review is to discuss the cellular defects associated with the muscle insulin resistance of the obese Zucker rat, as well as the mechanisms by which exercise training alleviates or compensates for these defects. Emphasis will be given to the importance of an increased GLUT4 expression on alleviating muscle insulin resistance. METHODS: A review of the relative research from my laboratory and the scientific literature was performed to obtain information on the muscle insulin resistance of the obese Zucker rat and its response to exercise training. RESULTS: CONCLUSION:
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Authors | John L Ivy |
Journal | Medicine and science in sports and exercise
(Med Sci Sports Exerc)
Vol. 36
Issue 7
Pg. 1207-11
(Jul 2004)
ISSN: 0195-9131 [Print] United States |
PMID | 15235327
(Publication Type: Journal Article, Review)
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Chemical References |
- Glucose Transporter Type 4
- Monosaccharide Transport Proteins
- Muscle Proteins
- Slc2a4 protein, mouse
- Slc2a4 protein, rat
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Topics |
- Animals
- Gene Expression
(physiology)
- Glucose Transporter Type 4
- Insulin Resistance
(genetics)
- Mice
- Mice, Obese
- Monosaccharide Transport Proteins
(genetics, metabolism)
- Muscle Fibers, Skeletal
(metabolism)
- Muscle Proteins
- Muscle, Skeletal
(metabolism)
- Physical Conditioning, Animal
- Protein Transport
- Rats
- Rats, Zucker
- United States
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