In-vitro and in-vivo anti-allergic actions of Arecae semen.

Abstract

The effects of various extracts from oriental medicinal herbs on mast cell-mediated allergic reactions have been investigated. Among the extracts, Arecae semen was the most potent inhibitor of antigen-induced degranulation in RBL-2H3 mast cells. A. semen inhibited DNP-BSA- and compound 48/80-induced degranulation in RBL-2H3 mast cells with IC(50) values of approximately 53 and 52 microg mL(-1), respectively, and inhibited compound 48/80-induced systemic anaphylaxis by 46% at 300 mg kg(-1) in mice. A. semen also inhibited the expression of TNF-alpha and the activation of mitogen activated protein kinase, ERK1/2, which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of the activating phosphorylation of ERK1/2. These results suggest that A. semen may be useful for the treatment of various immediate and delayed allergic diseases.

• Authors: Jun Ho Lee, Sung Ho Chang, Yun Sim Park, Erk Her, Hoi Young Lee, Jong Woo Park, Jeung Whan Han, Young Mi Kim, Wahn Soo Choi
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 56 Issue 7 Pg. 927-33 (Jul 2004) ISSN: 0022-3573 [Print] England
• PMID: 15233873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Allergic Agents
• Drugs, Chinese Herbal
• Tumor Necrosis Factor-alpha
• p-Methoxy-N-methylphenethylamine
• Mitogen-Activated Protein Kinase 1
• Mitogen-Activated Protein Kinase 3
• Mitogen-Activated Protein Kinases

Topics

• Anaphylaxis (chemically induced, prevention & control)
• Animals
• Anti-Allergic Agents (pharmacology, therapeutic use)
• Areca
• Cell Degranulation (drug effects)
• Dose-Response Relationship, Drug
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Fruit
• In Vitro Techniques
• Male
• Mast Cells (drug effects, physiology)
• Mice
• Mice, Inbred ICR
• Mitogen-Activated Protein Kinase 1 (metabolism)
• Mitogen-Activated Protein Kinase 3
• Mitogen-Activated Protein Kinases (metabolism)
• Phosphorylation
• Phytotherapy
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, biosynthesis)
• p-Methoxy-N-methylphenethylamine (pharmacology)