The term 'aerobic
vaginitis' defines a 'new' vaginal pathology that is neither classifiable as specific
vaginitis nor as
bacterial vaginosis. We studied a sample of 30 women with a clinical and microbiological diagnosis of aerobic
vaginitis and compared the efficacy and tolerability of
kanamycin and
meclocycline, two products commercially available in Italy in the form of vaginal
pessaries. In chronological order of enrollment, the patients were alternately treated with
kanamycin or
meclocycline; the dose of administration in both groups was of one
pessary per day for 6 days. The evaluation of the therapeutic efficacy was carried out both at the first check-up (7th-8th day) and at a second check-up (13th-16th day). At the first follow-up carried out immediately at the end of
therapy, the percentage of normalisation of clinical signs and symptoms was increased independently of the type of treatment in the case of moderate grade aerobic
vaginitis, while
kanamycin was produced a better effect in the group with severe aerobic
vaginitis. Furthermore, at the second follow-up, a direct correlation with recovery of vaginal homeostasis was demonstrated by the normalisation of the vaginal pH and by the presence of lactobacilli, only in
kanamycin treated group. In conclusion, our results showed the validity of the treatment with
kanamycin intravaginally in this recently recognised disease.