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Antituberculous activity of some aryl semicarbazone derivatives.

Abstract
During the course of our work on the synthesis and screening of new drugs for tuberculosis, we have identified N1-(4-acetamido phenyl)-N4-(2-nitro benzylidene) semicarbazone (1b), which inhibited in vitro Mycobacterium tuberculosis H(37)Rv; 100% inhibition at 1.56 microg/mL. This paper is first of its kind in which aryl semicarbazones are reported to possess antimycobacterials potency greater than p-aminosalicylic acid, ethionamide, ethambutol, ciprofloxacin and kanamycin.
AuthorsDharmarajan Sriram, Perumal Yogeeswari, Rathinasabapathy Thirumurugan
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 15 Pg. 3923-4 (Aug 02 2004) ISSN: 0960-894X [Print] England
PMID15225698 (Publication Type: Journal Article)
Chemical References
  • Antitubercular Agents
  • Semicarbazones
Topics
  • Antitubercular Agents (chemical synthesis, pharmacology)
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Mycobacterium tuberculosis (drug effects)
  • Semicarbazones (chemical synthesis, pharmacology)
  • Structure-Activity Relationship

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