Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside.

Abstract

We present a case of a 21-year-old woman suffering from diffuse large B-cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high-dose cytosine-arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed.

• Authors: David Planer, Tali Cukierman, Diana Liebster, Michael Ilsar, Tova Chajek-Shaul
• Journal: American journal of hematology (Am J Hematol) Vol. 76 Issue 3 Pg. 304-6 (Jul 2004) ISSN: 0361-8609 [Print] United States
• PMID: 15224375 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2004 Wiley-Liss, Inc.

Chemical References

• Cytarabine

Topics

• Adult
• Breast Neoplasms (drug therapy)
• Cytarabine (administration & dosage, adverse effects)
• Female
• Humans
• Lymphoma, B-Cell (drug therapy)
• Lymphoma, Large B-Cell, Diffuse (drug therapy)
• Uveitis, Anterior (chemically induced, drug therapy)