Abstract | BACKGROUND: METHODS: RESULTS: Cell staining was observed in the cytoplasm and the nucleus. In 66 patients without previous hormonal treatment, the percentage of cells that stained positively for CARM1 in benign prostate tissue specimens (mean values: cytoplasm, 23%; nucleus, 16%) was statistically significantly less than the percentage of positively stained cells in PIN (mean values: cytoplasm, 56%; nucleus, 30%; P < 0.001) and in prostatic adenocarcinoma specimens (mean values: cytoplasm, 79%; nucleus, 53%; P < 0.001). The difference between adenocarcinoma and PIN also was statistically significant (P < 0.001). The staining intensity for CARM1 was significantly lower in benign prostate tissue specimens compared with PIN and prostatic adenocarcinoma specimens (P < 0.001). In the 12 patients with androgen-independent prostatic adenocarcinoma, the expression of CARM1 was significantly increased when compared with patients without previous hormonal treatment. Expression of CARM1 was not correlated with age, Gleason score sum, pathologic stage, lymph node metastasis, extraprostatic extension, surgical margin status, vascular invasion, or perineural invasion. CONCLUSIONS: The authors found that overexpression of CARM1 was involved in the development of prostate carcinoma as well as androgen-independent prostate carcinoma. Since CARM1 is functionally different from most other transcriptional coactivators of the AR, it may serve as a new target for the treatment of hormone-independent prostate carcinoma.
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Authors | Heng Hong, Chinghai Kao, Meei-Huey Jeng, John N Eble, Michael O Koch, Thomas A Gardner, Shaobo Zhang, Lang Li, Chong-Xian Pan, Zhiqiang Hu, Gregory T MacLennan, Liang Cheng |
Journal | Cancer
(Cancer)
Vol. 101
Issue 1
Pg. 83-9
(Jul 01 2004)
ISSN: 0008-543X [Print] United States |
PMID | 15221992
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2004 American Cancer Society. |
Chemical References |
- Biomarkers, Tumor
- Receptors, Androgen
- Protein-Arginine N-Methyltransferases
- coactivator-associated arginine methyltransferase 1
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Prostatic Intraepithelial Neoplasia
(metabolism, pathology)
- Prostatic Neoplasms
(metabolism, pathology)
- Protein-Arginine N-Methyltransferases
(biosynthesis)
- Receptors, Androgen
(metabolism)
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