Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.

Abstract

PURPOSE:

To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season.

METHODS:

Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level.

RESULTS:

Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024).

CONCLUSIONS:

The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

• Authors: Simone Eperon, Alain Sauty, René Lanz, Annette Leimgruber, Floriana Lurati, Yan Guex-Crosier
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 242 Issue 11 Pg. 966-70 (Nov 2004) ISSN: 0721-832X [Print] Germany
• PMID: 15221302 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CCL11 protein, human
• Chemokine CCL11
• Chemokines, CC
• Chemotactic Factors, Eosinophil

Topics

• Adult
• Chemokine CCL11
• Chemokines, CC (metabolism)
• Chemotactic Factors, Eosinophil (metabolism)
• Conjunctivitis, Allergic (metabolism)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Prospective Studies
• Seasons
• Tears (metabolism)
• Up-Regulation