Potential organ or tumor imaging agents. 32. A triglyceride ester of p-iodophenyl pentadecanoic acid as a potential hepatic imaging agent.

Abstract

A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by gamma-camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent.

• Authors: S W Schwendner, J P Weichert, M A Longino, M D Gross, R E Counsell
• Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 19 Issue 6 Pg. 639-50 (Aug 1992) ISSN: 0883-2897 [Print] England
• PMID: 1522018 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Iodine Radioisotopes
• Iodobenzenes
• Lipoproteins
• Phosphatidylglycerols
• Triglycerides
• Triolein
• omega-(4-iodophenyl)pentadecanoic acid
• tripalmitin
• Lipase
• 1,2-dipalmitoylphosphatidylglycerol

Topics

• Animals
• Diabetes Mellitus, Experimental (metabolism)
• Dogs
• Evaluation Studies as Topic
• Female
• Gamma Cameras
• Humans
• Iodine Radioisotopes
• Iodobenzenes (metabolism, pharmacokinetics)
• Lipase (metabolism)
• Lipoproteins (metabolism)
• Liver (diagnostic imaging, enzymology, metabolism)
• Models, Biological
• Neoplasms (diagnostic imaging)
• Phosphatidylglycerols (pharmacokinetics)
• Radionuclide Imaging
• Rats
• Rats, Inbred Strains
• Tissue Distribution
• Triglycerides (metabolism, pharmacokinetics)
• Triolein (metabolism)