P-aminodiphenylamine induced biochemical changes in sex organs of male albino rats.

Abstract	Intraperitoneal administration of p-aminodiphenylamine (p-ADPA), an aromatic amine of wide industrial applications, / 42.5 mg/kg body weight for 180 days significantly decreased the activities of testicular lactate dehydrogenase and hyaluronidase and lactic acid content indicating arrest of spermatogenesis. Patchy necrosis of the testis was confirmed histopathologically. No change in testicular cholesterol, fructose content of coagulating glands and dorso-lateral prostate and activities of alkaline phosphatase in seminal vesicle and acid phosphatase in ventral prostate support normal androgenic status.
Authors	R L Singh, S K Khanna, G B Singh
Journal	Indian journal of experimental biology (Indian J Exp Biol) Vol. 30 Issue 2 Pg. 110-3 (Feb 1992) ISSN: 0019-5189 [Print] India
PMID	1521858 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Phenylenediamines Proteins 4-aminodiphenylamine Cholesterol L-Lactate Dehydrogenase Hyaluronoglucosaminidase
Topics	Animals Cholesterol (analysis) Genitalia, Male (drug effects, metabolism) Hyaluronoglucosaminidase (analysis) L-Lactate Dehydrogenase (analysis) Male Phenylenediamines (pharmacology) Proteins (analysis) Rats Rats, Inbred Strains

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