Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The results of recent studies clearly demonstrated that ALT-711, a breaker of advanced glycation end-products-related protein crosslinks, ameliorated the adverse cardiovascular and renal changes associated with aging, diabetes, and hypertension. In diabetic animals, ALT-711 improved left ventricular function, decreased ventricular collagen content and improved its solubility, reduced aortic stiffness, ameliorated diabetic nephrosclerosis, and improved renal function. In older spontaneously hypertensive rats, it reduced left ventricular mass and collagen content, reduced proteinuria, and extended survival. The results of recent studies also indicated that the effects of crosslinks breakers may be mediated in part via reduction in oxidative stress and profibrotic cytokines. SUMMARY:
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Authors | Dinko Susic, Jasmina Varagic, Jwari Ahn, Edward D Frohlich |
Journal | Current opinion in cardiology
(Curr Opin Cardiol)
Vol. 19
Issue 4
Pg. 336-40
(Jul 2004)
ISSN: 0268-4705 [Print] United States |
PMID | 15218393
(Publication Type: Journal Article, Review)
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Chemical References |
- Cross-Linking Reagents
- Glycation End Products, Advanced
- Thiazoles
- Collagen
- alagebrium
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Topics |
- Aging
- Animals
- Blood Pressure
(drug effects)
- Cardiovascular Diseases
(drug therapy)
- Collagen
(metabolism)
- Comorbidity
- Cross-Linking Reagents
(metabolism)
- Diabetes Mellitus
(physiopathology)
- Glycation End Products, Advanced
(antagonists & inhibitors, metabolism)
- Humans
- Hypertension
(complications, drug therapy, physiopathology)
- Kidney Failure, Chronic
(drug therapy)
- Rats
- Thiazoles
(pharmacology, therapeutic use)
- Treatment Outcome
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