HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Bronchioloalveolar carcinoma: a model for investigating the biology of epidermal growth factor receptor inhibition.

Abstract
Bronchioloalveolar carcinoma (BAC) is a previously uncommon subset of non-small cell lung cancer (NSCLC) with unique epidemiology, pathology, clinical features, radiographic presentation, and natural history compared with other NSCLC subtypes. Recent data suggest that the incidence of BAC is increasing, notably in younger nonsmoking women. Despite reports of prolonged survival after repeated surgical resection of multifocal lesions and slow growth kinetics, advanced bilateral or recurrent diffuse BAC remains incurable, with the vast majority of patients dying of respiratory failure or intercurrent pneumonia within 5 years. Limited data suggest that chemotherapy may yield poor results in BAC. However, anecdotal reports of prolonged complete response to tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR), a member of the human epidermal growth factor receptor (erbB) family, have raised considerable interest in studying this NSCLC subset. Here we present clinical data and preliminary results of correlative science studies analyzing human epidermal growth factor receptor pathways from the following two prospective Southwest Oncology Group clinical trials performed in advanced stage BAC: S9714 testing a 96-h continuous infusion of paclitaxel (Taxol) and S0126 evaluating the small molecule EGFR inhibitor gefitinib (ZD1839 or Iressa). These studies provide a biological rationale for investigating BAC as a model of predictive markers of EGFR inhibition.
AuthorsDavid R Gandara, Howard West, Kari Chansky, Angela M Davies, Derick H M Lau, John Crowley, Paul H Gumerlock, Fred R Hirsch, Wilbur A Franklin
JournalClinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 10 Issue 12 Pt 2 Pg. 4205s-4209s (Jun 15 2004) ISSN: 1078-0432 [Print] United States
PMID15217959 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Biomarkers, Tumor
  • Quinazolines
  • ErbB Receptors
  • Paclitaxel
  • Gefitinib
Topics
  • Adenocarcinoma, Bronchiolo-Alveolar (physiopathology)
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Antineoplastic Agents, Phytogenic (administration & dosage, therapeutic use)
  • Biomarkers, Tumor (analysis)
  • Clinical Trials as Topic
  • ErbB Receptors (drug effects, physiology)
  • Gefitinib
  • Humans
  • Lung Neoplasms (physiopathology)
  • Paclitaxel (administration & dosage, therapeutic use)
  • Prognosis
  • Quinazolines (administration & dosage, therapeutic use)
  • Signal Transduction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: