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Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.

Abstract
A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.
AuthorsGeorge R Pettit, Qingwen Zhang, Véronique Pinilla, Delbert L Herald, Dennis L Doubek, James A Duke
JournalJournal of natural products (J Nat Prod) Vol. 67 Issue 6 Pg. 983-5 (Jun 2004) ISSN: 0163-3864 [Print] United States
PMID15217278 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Pentacyclic Triterpenes
  • Phenols
  • Triterpenes
  • gustastatin
  • Oleanolic Acid
  • beta-amyrin
  • Betulinic Acid
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Brazil
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Lecythidaceae (chemistry)
  • Leukemia P388
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oleanolic Acid (analogs & derivatives, chemistry, isolation & purification, pharmacology)
  • Pentacyclic Triterpenes
  • Phenols (chemistry, isolation & purification, pharmacology)
  • Plants, Medicinal (chemistry)
  • Trees
  • Triterpenes (chemistry, isolation & purification, pharmacology)
  • Betulinic Acid

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