FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. I. Taxonomy, fermentation, isolation, physico-chemical properties.

Abstract

FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis in human hepatoma cell line Hep G2. These compounds also have in vitro antifungal activity against Candida albicans and Aspergillus fumigatus.

• Authors: Hidetaka Hatori, Toshihiro Shibata, Yasuhisa Tsurumi, Tomoko Nakanishi, Masaaki Katsuoka, Yoshihiro Ohtsu, Kazutoshi Sakamoto, Shigehiro Takase, Hirotsugu Ueda, Motohiro Hino, Takashi Fujii
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 57 Issue 4 Pg. 253-9 (Apr 2004) ISSN: 0021-8820 [Print] England
• PMID: 15217189 (Publication Type: Journal Article)

Chemical References

• Anticholesteremic Agents
• FR171456
• Cholesterol

Topics

• Anticholesteremic Agents (chemistry, isolation & purification, metabolism, pharmacology)
• Ascomycota (chemistry, metabolism)
• Aspergillus fumigatus (drug effects)
• Candida albicans (drug effects)
• Cell Line, Tumor
• Cholesterol (analogs & derivatives, chemical synthesis, chemistry, isolation & purification, pharmacology)
• Fermentation
• Humans
• Inhibitory Concentration 50
• Molecular Structure
• Molecular Weight
• Nuclear Magnetic Resonance, Biomolecular
• Spectrometry, Mass, Fast Atom Bombardment