Abstract | OBJECTIVE: METHODS: A sensitive and specific DNP radioimmunoassay was performed on venous blood samples obtained on post-SAH Days 1, 3, and 7 from 10 consecutive SAH patients (cases) and randomly from 9 healthy volunteers (controls). Clinical and laboratory data, including daily serum sodium concentration and fluid balance, were collected prospectively up to 7 days after the ictus. RESULTS: Increase in plasma DNP levels occurred in five (63%) of eight patients who had DNP levels measured on Days 1 and 3 (mean increase, 29%). An increase in DNP level was significantly associated with development of a negative fluid balance (P = 0.003) and hyponatremia (P = 0.008). Three (75%) of the four patients who developed cerebral vasospasm during this study experienced an increase in DNP levels from Days 1 to 3. CONCLUSION: The present study is the first to find a significant association between elevated levels of DNP, a new member of the natriuretic peptide family, and the development of diuresis and natriuresis in patients with aneurysmal SAH. Our findings warrant further investigation by means of a large-scale, prospective, case-control study.
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Authors | Vini G Khurana, Eelco F M Wijdicks, Denise M Heublein, Robyn L McClelland, Fredric B Meyer, David G Piepgras, John C Burnett Jr |
Journal | Neurosurgery
(Neurosurgery)
Vol. 55
Issue 1
Pg. 69-75; discussion 75-6
(Jul 2004)
ISSN: 0148-396X [Print] United States |
PMID | 15214975
(Publication Type: Journal Article)
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Chemical References |
- Dendroaspis natriuretic peptide
- Elapid Venoms
- Intercellular Signaling Peptides and Proteins
- Natriuretic Peptides
- Peptides
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Topics |
- Adult
- Aged
- Case-Control Studies
- Diuresis
(physiology)
- Elapid Venoms
(blood)
- Female
- Humans
- Hyponatremia
(blood, etiology)
- Intercellular Signaling Peptides and Proteins
- Male
- Middle Aged
- Natriuretic Peptides
(blood)
- Peptides
(blood)
- Pilot Projects
- Subarachnoid Hemorrhage
(blood, complications)
- Time Factors
- Vasospasm, Intracranial
(blood, etiology)
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