Ganstigmine and donepezil improve neurodegeneration in AD11 antinerve growth factor transgenic mice.

Abstract

Ganstigmine (CHF2819) is an acetylcholinesterase inhibitor that increases acetylcholine in rat hippocampus and ameliorates scopolamine-induced amnesia. In this article, we examined whether and how ganstigmine might prevent or rescue the neurodegenerative phenotype in AD11 antinerve growth factor (anti-NGF) mice, a transgenic model for Alzheimer's disease. The effects of ganstigmine were compared with those obtained after administration of donepezil. Results demonstrate that intraperitoneal and oral administration of ganstigmine and donepezil can reverse the cholinergic and behavioral deficit in AD11 mice but not the amyloid and phosphotau accumulation, uncovering different mechanisms leading to neurodegeneration in AD11 mice.

• Authors: Simona Capsoni, Sabina Giannotta, Marco Stebel, Addys Ancheta Garcia, Roberta De Rosa, Gino Villetti, Bruno Pietro Imbimbo, Claudio Pietra, Antonino Cattaneo
• Journal: American journal of Alzheimer's disease and other dementias (Am J Alzheimers Dis Other Demen) 2004 May-Jun Vol. 19 Issue 3 Pg. 153-60 ISSN: 1533-3175 [Print] United States
• PMID: 15214201 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Antibodies
• Carbamates
• Cholinesterase Inhibitors
• Indans
• Piperidines
• tau Proteins
• Donepezil
• Nerve Growth Factor
• ganstigmine

Topics

• Administration, Oral
• Alkaloids (administration & dosage, pharmacology, therapeutic use)
• Alzheimer Disease (drug therapy, pathology)
• Amyloid beta-Peptides (metabolism)
• Amyloid beta-Protein Precursor (metabolism)
• Animals
• Antibodies (immunology)
• Behavior, Animal (drug effects)
• Carbamates (administration & dosage, pharmacology, therapeutic use)
• Cholinesterase Inhibitors (administration & dosage, pharmacology, therapeutic use)
• Donepezil
• Immunohistochemistry
• Indans (administration & dosage, pharmacology, therapeutic use)
• Injections, Intraperitoneal
• Mice
• Mice, Transgenic
• Nerve Degeneration (drug therapy, pathology, prevention & control)
• Nerve Growth Factor (antagonists & inhibitors, drug effects)
• Phosphorylation (drug effects)
• Piperidines (administration & dosage, pharmacology, therapeutic use)
• tau Proteins (metabolism)