Abstract | OBJECTIVE: SUMMARY BACKGROUND DATA:
Incisional hernias complicate 11% of abdominal wall closures, resulting in 200,000 incisional hernia repairs in the United States each year. Mechanical improvements alone in mesh, suture material, and surgical technique have failed to reduce the high rate of fascial wound failure. METHODS: RESULTS: Treatment with bFGF rods significantly increased fascial wound breaking strength. In the " hernia-prevention" experiments, incisional hernias developed in 90% of untreated incisions, 60% of control-rod incisions, and only 30% of bFGF-rod incisions (P < 0.05). In the " hernia-treatment" experiments, recurrent incisional hernias developed in 86% of control-rod incisions compared with only 23% of bFGF-rod treated incisions (P < 0.05). Immunohistochemistry demonstrated increased angiogenesis and collagen protein production in bFGF treated incisions. CONCLUSION: The treatment of abdominal fascial incisions with a sustained-release bFGF polymer significantly lowered the incidence of incisional hernias and the recurrence rate after repair.
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Authors | Derek A Dubay, Xue Wang, M Ann Kuhn, Martin C Robson, Michael G Franz |
Journal | Annals of surgery
(Ann Surg)
Vol. 240
Issue 1
Pg. 179-86
(Jul 2004)
ISSN: 0003-4932 [Print] United States |
PMID | 15213634
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Delayed-Action Preparations
- Drug Carriers
- Drug Implants
- Polymers
- Fibroblast Growth Factor 2
- Collagen
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Topics |
- Abdominal Muscles
(physiology)
- Abdominal Wall
(surgery)
- Animals
- Biomechanical Phenomena
- Collagen
(biosynthesis)
- Delayed-Action Preparations
- Drug Carriers
- Drug Implants
- Fascia
(metabolism, physiology)
- Fibroblast Growth Factor 2
(administration & dosage)
- Hernia, Ventral
(drug therapy, etiology, prevention & control)
- In Vitro Techniques
- Male
- Neovascularization, Physiologic
- Polymers
- Postoperative Complications
(prevention & control)
- Rats
- Rats, Sprague-Dawley
- Tensile Strength
- Wound Healing
(drug effects)
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