Deletion 12p in de novo acute myeloid leukemia. An association with early progenitor cell.

Abstract

Deletion of the short arm of chromosome 12 as the sole karyotypic abnormality was found in three cases of acute myeloblastic leukemia (AML). In contrast to what has previously been reported in the literature, none of our cases had an antecedent history of myelodysplasia or toxic exposure, and basophilia was absent. Two cases were terminal deoxynucleotidyl transferase (TdT) positive, suggesting involvement of an early progenitor cell.

• Authors: L C Chan, Y L Kwong, H W Liu, C P Lee, K W Lie, A Y Chan
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 62 Issue 1 Pg. 47-9 (Aug 1992) ISSN: 0165-4608 [Print] United States
• PMID: 1521233 (Publication Type: Case Reports, Journal Article)

Chemical References

• DNA Nucleotidylexotransferase

Topics

• Adult
• Aged
• Aged, 80 and over
• Chromosome Deletion
• Chromosomes, Human, Pair 12
• DNA Nucleotidylexotransferase
• Female
• Humans
• Leukemia, Myeloid, Acute (genetics)
• Male