Nasal corticosteroids for children with snoring.

Abstract

Nasal corticosteroids improve polysomnography indices but not symptoms in children with mild to moderate sleep-disordered breathing. We hypothesized that administration of nasal corticosteroids for 4 weeks to snoring children with only mild elevation in their apnea-hypopnea index would improve both polysomnography findings and symptoms of sleep-disordered breathing. Budesonide 50 mcg per nostril twice daily was administered for 4 weeks to children (2-14 years old) with habitual snoring and an apnea-hypopnea index of 1-10 episodes/hr. Subjects were evaluated before treatment and at 2 weeks and 9 months after its completion. Primary outcome variables were changes in apnea-hypopnea index and symptom score. Twenty-seven children were studied. At 2 weeks, the mean apnea-hypopnea index decreased from 5.2 (+/-2.2) episodes/hr to 3.2 (+/-1.5) episodes/hr, and median oxygen desaturation of hemoglobin index fell from 3.1 (0.4-8.2) to 1.9 (0.2-5.4) (P < 0.0001). Mean symptom score was 1.33 (+/-2.11) at baseline, and decreased to -0.008 (+/-2.24) at 2 weeks after treatment and to -1.08 (+/-1.75) at 9 months after treatment (P < 0.05). Four weeks of nasal budesonide improved both polysomnography findings and symptoms in children with mild sleep-disordered breathing. The clinical effect is maintained for several months after treatment.

• Authors: Emmanouel I Alexopoulos, Athanasios G Kaditis, Efthimia Kalampouka, Eleni Kostadima, Nikiforos V Angelopoulos, Vasiliki Mikraki, Nikolaos Skenteris, Konstantinos Gourgoulianis
• Journal: Pediatric pulmonology (Pediatr Pulmonol) Vol. 38 Issue 2 Pg. 161-7 (Aug 2004) ISSN: 8755-6863 [Print] United States
• PMID: 15211701 (Publication Type: Journal Article)
• Copyright: Copyright 2004 Wiley-Liss, Inc.

Chemical References

• Adrenal Cortex Hormones
• Bronchodilator Agents
• Budesonide

Topics

• Administration, Intranasal
• Adolescent
• Adrenal Cortex Hormones (administration & dosage, therapeutic use)
• Bronchodilator Agents (administration & dosage, therapeutic use)
• Budesonide (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Female
• Follow-Up Studies
• Humans
• Male
• Patient Selection
• Polysomnography
• Sleep Apnea, Obstructive (drug therapy)
• Snoring (drug therapy)