Open-label dose-escalation study of oral 1-octanol in patients with essential tremor.

Abstract

Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.

• Authors: H A Shill, K O Bushara, Z Mari, M Reich, M Hallett
• Journal: Neurology (Neurology) Vol. 62 Issue 12 Pg. 2320-2 (Jun 22 2004) ISSN: 1526-632X [Electronic] United States
• PMID: 15210907 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Drugs, Investigational
• 1-Octanol

Topics

• 1-Octanol (administration & dosage, therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Drugs, Investigational (administration & dosage, therapeutic use)
• Essential Tremor (drug therapy)
• Humans
• Middle Aged