Abstract | BACKGROUND: OBJECTIVE: METHODS:
delta-Aminolevulinic acid was applied topically on lesions 1 to 5 hr before light treatment. Lesions were illuminated with 417+/-5-nm blue light for 1000 sec (10 J/cm(2)). Two consecutive treatments 1 week apart were administered as a therapeutic course. Each patient underwent two courses of photodynamic therapy with delta-aminolevulinic acid 2 to 4 months apart. The reported assessment was made 8 months after initial treatment. In most sessions the entire face, rather than visible basal cell carcinomas only, was treated. The treated basal cell carcinomas were clinically subdivided to superficial or nodular type guided by their morphologic features. A total of 9 superficial and 16 nodular basal cell carcinomas on the face and 27 superficial basal cell carcinomas on the lower extremities were treated. RESULTS: Complete clinical response was observed in 8 of 9 (89%) superficial basal cell carcinomas and 5 of 16 (31%) nodular basal cell carcinomas on the face and in 18 of 27 (67%) of superficial basal cell carcinomas on the lower extremities. The remaining 21 lesions showed partial clinical resolution. No new basal cell carcinomas were observed during the 8-month follow-up period in areas treated with a broad application technique. Resolution of the lesions was accompanied by an excellent cosmetic outcome and decreased prominence of old surgical scars in the more severely affected patient. Treatments were well tolerated, but associated with moderate to severe stinging during illumination. CONCLUSION:
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Authors | Aleksandr Itkin, Barbara A Gilchrest |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 30
Issue 7
Pg. 1054-61
(Jul 2004)
ISSN: 1076-0512 [Print] United States |
PMID | 15209801
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Adult
- Aminolevulinic Acid
(therapeutic use)
- Basal Cell Nevus Syndrome
(drug therapy)
- Carcinoma, Basal Cell
(drug therapy)
- Female
- Humans
- Middle Aged
- Neoplasms, Multiple Primary
(drug therapy)
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
- Skin Neoplasms
(drug therapy)
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