[Study on the injury effect of ammonium perchlorate to lung].

Abstract

OBJECTIVE:

To study the injury effect of ammonium perchlorate (AP) to lung and to explore whether AP can cause pulmonary fibrosis.

METHODS:

To detect the levels of cell counts, TNF-alpha, MDA, HYP and the synthesis of collagen in BALF or rat lung after a certain time when rats were injected AP by intratracheal instillation.

RESULTS:

AP could bring about acute lung damage and inflammatory reaction. The levels of TNF-alpha of different groups in different time were obviously higher than the normal control group(P < 0.05). AP could affect the levels of MDA, HYP and the synthesis of collagen. But it had no obviously pathological change of pulmonary fibrosis.

CONCLUSION:

There were acute injury effect about AP to lung, but this experiment could not make sure whether AP could cause pulmonary fibrosis.

• Authors: Haibing Yang, Kailiang Peng, Qilong Chu, Suli Zhao
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 33 Issue 2 Pg. 208-10 (Mar 2004) ISSN: 1000-8020 [Print] China
• PMID: 15209008 (Publication Type: English Abstract, Journal Article)

Chemical References

• Perchlorates
• Quaternary Ammonium Compounds
• Tumor Necrosis Factor-alpha
• Malondialdehyde
• Hydroxyproline
• ammonium perchlorate

Topics

• Animals
• Bronchoalveolar Lavage Fluid (chemistry)
• Female
• Hydroxyproline (analysis)
• Lung (metabolism, pathology)
• Malondialdehyde (analysis)
• Perchlorates (toxicity)
• Pulmonary Fibrosis (chemically induced)
• Quaternary Ammonium Compounds (toxicity)
• Rats
• Rats, Wistar
• Tumor Necrosis Factor-alpha (analysis)