[Inhibitory effect on mammary carcinoma cells induced by beta-ionone].

Abstract

OBJECTIVE:

To investigate the effect of cell proliferation induced by beta-ionone.

METHODS:

Human mammary cancer cells (MCF-7) were treated with various beta-ionone concentrations (25, 50, 100 and 200 mumol/L), with a negative control. Methods such as curve of cell growth, cellular mitosis, the cell clone formatting and DNA synthesis were employed.

RESULTS:

beta-ionone inhibited the cell proliferation, cellular mitosis, the cell clone formatting and DNA synthesis. The inhibitory frequency (IF) showed a dose-dependent response as the concentrations of beta-ionone increased. Its IC50 value was 104 mumol/L for MCF-7 cells. The inhibitory frequency (IF) from cellular mitosis of MCF-7 treated by beta-ionone were - 12.88% - 68.67% at 24 h and 20.79% - 87.79% at 48 h, from the cell clone formatting of MCF-7 treated by beta-ionone, were - 14.11% - 65.18% at 24 h and 6.58% - 72.48% at 48 h, from DNA synthesis, 16.75% - 65.33% at 24 h and 35.10% - 81.89% at 48 h.

CONCLUSION:

beta-ionone could inhibit the cell growth of MCF-7 cells and the mechanisms needs to be further studied.

• Authors: Jiaren Liu, Baixiang Li, Ruobo Ma, Bingqing Chen
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 33 Issue 2 Pg. 151-3, 157 (Mar 2004) ISSN: 1000-8020 [Print] China
• PMID: 15208992 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Norisoprenoids
• beta-ionone

Topics

• Adenocarcinoma (pathology)
• Antineoplastic Agents (pharmacology)
• Breast Neoplasms (pathology)
• Cell Division (drug effects)
• DNA, Neoplasm (biosynthesis, drug effects)
• Female
• Humans
• Norisoprenoids (pharmacology)
• Tumor Cells, Cultured