HPLC profiling of Trp-related metabolites in humans.

Abstract

Screening for metabolic abnormalities of Trp has been introduced using SPE pre-treatment, TLC and/or two HPLC procedures. The excretory pattern in urine (occasionally also plasma and CSF levels) has been followed in a group of 390 children showing various symptoms of a metabolic defect and in 195 patients with skin diseases, namely those associated with photosensitivity, such as porphyria, vitiligo, alopecia, psoriasis, erythematodes, and others. Excretory abnormalities of either indican, kynurenine, 3-hydroxyanthranilic acid or indolylacryloylglycine have been occasionally combined with myopathy, seizures, liver and intestinal symptoms. Several indoles and kynurenine derivatives present changes in the alopecia group and the vitiliginous patients.

• Authors: Eliska Marklová, Ziad Albahri, Marie Nozicková
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 527 Pg. 739-44 ( 2003) ISSN: 0065-2598 [Print] United States
• PMID: 15206797 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tryptophan

Topics

• Adolescent
• Adult
• Aged
• Case-Control Studies
• Child
• Child, Preschool
• Chromatography, High Pressure Liquid (methods)
• Humans
• Infant
• Metabolism, Inborn Errors (metabolism)
• Middle Aged
• Photosensitivity Disorders (metabolism)
• Skin Diseases (metabolism)
• Tryptophan (analogs & derivatives, analysis, metabolism)