Abstract | OBJECTIVE: The aim of this study was to differentiate between the peripheral and central analgesic and antihyperalgesic properties of systemic procaine hydrochloride in standardized human pain models. METHOD:
Subcutaneous injections of either 150 mg procaine hydrochloride or saline solution were administered at intervals of 2 weeks on a randomized and double blind basis. During the 90-min infusion and subsequent 60-min monitoring periods, touch sensitivity was determined and in addition two experimental hyperalgesic models were analyzed. RESULTS: CONCLUSION:
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Authors | U Gerdemann, V Brückl, N A S Nassr, D Märkert, R Sittl, W Koppert |
Journal | Schmerz (Berlin, Germany)
(Schmerz)
Vol. 18
Issue 3
Pg. 189-96
(Jun 2004)
ISSN: 0932-433X [Print] Germany |
Vernacular Title | Differenzierung peripherer und zentraler antihyperalgetischer Effekte einer systemischen Procaindauerinfusion. |
PMID | 15206017
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anesthetics, Local
- Procaine
- Capsaicin
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Topics |
- Anesthetics, Local
(administration & dosage, therapeutic use)
- Capsaicin
(administration & dosage)
- Double-Blind Method
- Humans
- Hyperalgesia
(drug therapy, physiopathology)
- Infusions, Parenteral
- Injections, Subcutaneous
- Nociceptors
(drug effects, physiology)
- Pain Measurement
- Procaine
(administration & dosage, therapeutic use)
- Time Factors
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